BTK (fosfo-Tyr223) Antilichaam

Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK.

695

Q06187

NP_000052.1

Human, Mouse, Rat

BTK (phospho Tyr223) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 223 (A-L-Y (p) -D-Y) derived from Human BTK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

80 kDa

IgG

The antibody detects endogenous levels of BTK only when phosphorylated at tyrosine 223.

Western Blot: 1:500~1:1000

BTK

Bruton agammaglobulinemia tyrosine kinase

Homo sapiens

Sulekha Verma, J. Biol. Chem., Feb 2001; 276: 4671 - 4676.

Yan M. Li, Cancer Res., Nov 2003; 63: 7630 - 7633.

Malti Nikrad, Mol. Cancer Ther., Mar 2005; 4: 443 - 449.

Feng Dong, Infect. Immun., Mar 2005; 73: 1861 - 1864.

AGMX1, ATK, kinase Btk, BPK

WB

547759

Liquid