BTLA Antilichaam

The B- and T-lymphocyte attenuator (BTLA) protein is a member of the immunoglobulin superfamily containing a single immunoglobulin (Ig) domain (1) . Like other coihibitory receptors such as CTLA-4 and PD-1, BTLA functions as a receptor that relays inhibitory signals to suppress the immune response, and can inhibit LPS-induced endotoxic shock by suppressing TLR4 signaling in innate immune cells (1,2) . Polymorphisms in this gene have also been associated with an increased risk of rheumatoid arthritis (3) .

151888

Q7Z6A9

NP_861445

Human

Unconjugated

Primary Antibodies

Innate Immunity

BTLA Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

BTLA Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

BTLA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

BTLA antibody is human specific. At least two isoforms of BTLA are known to exist.

BTLA

Cat. No. 11-801 - Human Small Intestine Tissue Slide

B and T lymphocyte associated

Homo sapiens

Carreno BM and Collins M. BTLA: a new inhibitory receptor with a B7-like ligand. Trends Immunol. 2003; 24:524-7.

Kobayashi Y, Iwata A, Suzuki K, et al. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. USA 2013; 110:5121-6.

Lin SC, Kuo CC, and Chan CH. Association of a BTLA gene polymorphism with a risk of rheumatoid arthritis. J. Biomed. Sci. 2006; 13:853-60.

BTLA Antibody : BTLA1, CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein

ELISA, WB, IHC-P, IF

145580621

Liquid