BTS-67582

BTS-67582 is an orally active nonsulfonylurea insulinotropic agent and potassium channel blocker. BTS-67582 affects the K+ ATP channel in the islet cell but at a different binding site than the sulfonylureas. BTS-67582 is an antidiabetic agent[1][2].

161748-40-9

12352005

Potassium Channel

Membrane Transporter/Ion Channel

Inflammation/Immunology; Metabolic Disease

N=C(NC1=CC=CC=C1N2CCOCC2)N(C)C.O=C(O)/C=C/C(O)=O

C17H24N4O5

364.40

[1]Skillman CA, Raskin P. A double-masked placebo-controlled trial assessing effects of various doses of BTS 67,582, a novel insulinotropic agent, on fasting hyperglycemia in NIDDM patients. Diabetes Care. 1997 Apr;20 (4) :591-6. 7,582, a Novel Insulinotropic Agent, on Fasting Hyperglycemia in NIDDM Patients|[2]Louchami K, et al. Effect of 1,1-dimethyl-2-[2-morpholinophenyl]guanidine fumarate on pancreatic islet function. Eur J Pharmacol. 1998 Jul 10;352 (2-3) :289-97.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19174/

Reference compound1

Phase 2