BVT-2733 (hydrochloride)

BVT-2733 hydrochloride is a potent, selective and orally active nonsteroidal 11β-HSD1 inhibitor. BVT-2733 hydrochloride is more potent against mouse 11β-HSD1 enzyme (IC50=96 nM) than against human 11β-HSD1 enzyme (IC50=3341 nM) . BVT-2733 hydrochloride has the potential to be used in the study of arthritis and obesity-related diseases[1][2][3].

376641-65-5

12352005

H302-H315-H319-H335

11β-HSD

Metabolic Enzyme/Protease

COVID-19-immunoregulation

Inflammation/Immunology

O=S(C1=CC=CC(Cl)=C1C)(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)=O.Cl

C17H22Cl2N4O3S2

465.42

P261-P280-P302+P352

[1]11β-hydroxydehydrogenase 1 (11β-HSD1) Inhibitor in Development|[2]Zhang L, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17 (3) :489-94.|[3]Wang L, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7 (7) :e40056.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-18054A/

Reference compound1

No Development Reported