C-Met (fosfo-Tyr1003) Antilichaam

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.

4233

P08581

NP_000236.2

Human, Mouse, Rat

C-Met (phospho Tyr1003) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1003 (V-D-Y (p) -R-A) derived from Human c-Met.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

155 kDa

IgG

The antibody detects endogenous level of c-Met only when phosphorylated at tyrosine 1003.

Western Blot: 1:500~1:1000

MET

Met proto-oncogene

Homo sapiens

Usatyuk PV, et al. (2014) J Biol Chem. Asiedu MK, et al. (2014) Oncogene 33, 1316-24. Dulak AM, et al. (2011) Oncogene 30, 3625-35.

HGF receptor, HGF-SF receptor, Hepatocyte growth factor receptor precursor, Hepatocyte growth factor receptor precursor, Met proto- oncogene tyros

WB

42741655

Liquid