C-Myc Antilichaam

The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

4609

P01106

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human c-Myc (NP_002458.2) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Stem Cell, Transcription

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 49kDa

IgG

WB: 1:500 - 1:2000

MYC

HL-60

MCF7

Mouse liver

V-myc avian myelocytomatosis viral oncogene homolog

Homo sapiens

MYC, c-Myc, MRTL, MYCC, bHLHe39

WB

Liquid