C1orf187 Polyklonal Antibody, Biotin Conjugated

C1orf187, also known as Draxin, Dorsal repulsive axon guidance protein and Neucrin, is a 349 amino acid secreted protein that is required of the development of the spinal cord and forebrain commissures. C1orf187 acts as a chemorepulsive guidance protein and directs commissural axons during development by repelling neurite outgrowth from the spinal cord. During development, C1orf187 modulates neural crest migration by reducing the polarization of these cells, leading to reduced velocity of migration and increased frequency of changing direction, leading to a net decrease in migrational distance. It acts as an antagonist of the Wnt signaling pathway by inhibiting the stabilization of cytosolic _-catenin via its interaction with LRP6. C1orf187 inhibits outgrowth from the olfactory bulb and likely contributes to the formation of the lateral olfactory tract.

AGPA3119; C1orf187; Chromosome 1 open reading frame 187; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; DRAXI_HUMAN; Draxin; FLJ34999; MGC117222; Neucrin; OTTHUMP00000002262; UNQ3119.

374946

Extracellular matrix

251-349/349

C1orf187

Biotin

KLH conjugated synthetic peptide derived from human C1orf187

WB, ELISA, IHC-P, IHC-F

Purified by Protein A.

1µg/µl

WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500)

Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Unmodified

Store at -20°C for 12 months.

374946

Human, Mouse, Rat, Cow, Sheep, Pig, Horse, Chicken, Rabbit