C2 Antilichaam

Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.

717

P06681

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 453-752 of human C2 (NP_000054.2) .

Unconjugated

Primary Antibodies

Immunology, Innate Immunity

Affinity purification

LO2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 70kDa/110kDa

IgG

WB: 1:500 - 1:2000

C2

293T

U-87MG

Complement component 2

Homo sapiens

C2, CO2, DKFZp779M0311, ARMD14

WB

Liquid