C2CD3 Antilichaam

C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1) . It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of proteins and regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins (2,3) . C2CD3 directly promotes centriole elongation and OFD1 acts as a negative regulator of C2CD3 (4,5) .

26005

Q4AC94

NP_001273506

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Signal Transduction

C2CD3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

C2CD3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

C2CD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

C2CD3 antibody is human, mouse and rat reactive.

C2CD3

C2 calcium-dependent domain containing 3

Homo sapiens

Hoover AN, Wynkoop A, Zeng H, et al. C2cd3 is required for cilia formation and Hedgehog signaling in mouse. Development 2008; 135:4049-58.

Ye X, Zeng H, Ning G, et al. C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals. Proc. Natl. Acad. Sci. USA 2014; 111:2164-9.

Thauvin-Robinet C, Lee JS, Lopez E, et al. The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation. Nat. Genet. 2014; 46:905-11.

Balestra FR, Strnad P, Fluckiger I, et al. Discovering regulators of centriole biogenesis through siRNA-based functional genomics in human cells. Dev. Cell 2013; 25:555-71.

C2 calcium-dependent domain containing 3, C2 domain-containing protein 3

ELISA, WB

148596944

Liquid