C3 Antilichaam

Human complement component C3. Complement C3 contains two chains linked by a disulfide bond. Its activation by a C3 convertase releases the C3a anaphylatoxin from the amino end of the α chain and generates C3b, which associates with the Bb fragment of complement factor B to form the alternative-complement-pathway C3/C5 convertase.C3a anaphylatoxin is a vasoactive peptide and a mediator of inflammation. C3b, with its highly reactive thiol group, binds to the surface of foreign particles and facilitates phagocytosis. It binds to complement C5 and renders it susceptible to proteolysis by the classical-complement-pathway C3/C5 convertase. The activity of C3b is regulated by proteolytic cleavage involving factors H and I. Its degradation products can also be biologically active.

718

P01024

NP_000055.1

Human

Plasma protein

Unconjugated

Primary Antibodies

Signal Transduction

Antigen affinity-purified

1 mg/mL

Phosphate-Buffered Saline. No preservatives added.

None

Blue Ice

C3 antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

187.2 kDa (calculated)

C3 antibody can be used for the detection of C3 by Western blot, ELISA, may also work for IHC and ICC.

C3

Complement component 3

Homo sapiens

De Bruijn, M. H. and Fey, G. H. Human complement component C3: cDNA coding sequence and derived primary structure. Proc. Natl. Acad. Sci. U. S. A. 82 (3), 708-712 (1985) .

CPAMD1, Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, ASP, C3a, C3b, AHUS5, ARMD9, CPAMD1, HEL-S-62p

ELISA

4557385

Liquid