Ca2+ -Langerin-IN-1

Ca2+-Langerin-IN-1 (Compound 3) is a allosteric Langerin inhibitor. Langerin is a C-type lectin that is expressed on Langerhans cells and plays a crucial role in pathogen recognition and innate immune activation. The KD value of the CRD domain of murine Langerin protein for Ca2+-Langerin-IN-1 is 17 μM under the presence of Ca²⁺ and 53 μM under the absence of Ca²⁺ competition. Ca2+-Langerin-IN-1 induces conformational changes and competitively replaces Ca²⁺, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+-Langerin-IN-1 can be used in the research of immunomodulatory therapy[1].

79932-56-2

12352005

H302-H315-H319-H335

Calcium Channel

Membrane Transporter/Ion Channel; Neuronal Signaling

Inflammation/Immunology

O=C1C(C(O)=O)=CN=C2N1C(C)=C(C)S2

C9H8N2O3S

224.24

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Ning Y, et al. Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. J Med Chem. 2025 Dec 11;68 (23) :24924-24934.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W069974/

Reference compound2

No Development Reported