CACNA1H Antilichaam

The calcium channel protein CACNA1H is a T-type member of the alpha-1 subunit family that is part of the voltage-dependent calcium channel complex which mediates the influx of calcium ions into the cell upon membrane polarization (1,2) . CACNA1H is a subunit of Cav3.2 T-type calcium channel that is involved in neurological disorders such as epilepsy and pain (2,3) . CACNA1H associates with the caveolin protein Cav-3 and it is thought that Cav-3 regulates the Protein Kinase A (PKA) modulation of CACNA1H-containing Cav3.2 T-type calcium channels (4) .

8912

O95180

NP_066921

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

CACNA1H antibody is affinity chromatography purified via peptide column.

Cat. No. 1210 - HEK293 Cell Lysate

1 mg/mL

CACNA1H antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CACNA1H antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

CACNA1H antibody is human, mouse and rat reactive. Multiple isoforms of CACNA1H are known to exist.

CACNA1H

Calcium channel, voltage-dependent, T type, alpha 1H subunit

Homo sapiens

Cribbs LL, Lee JH, Yang J, et al. Cloning and characterization of alpha1H from human heart, a member of the T-type CA2+ channel gene family. Circ. Res. 1998; 83:103-9.

Sekiguchi F and Kawabata A. T-type calcium channels: functional regulation and implication in pain signaling. J. Pharmacol. Sci. 2013; 122:244-50.

McGivern JG. Targeting N-type and T-type calcium channels for the treatment of pain. Drug Discov. Today 2006; 11:245-53.

Markandeya YS, Fahey JM, Pluteanu F, et al. Caveolin-3 regulates protein kinase A modulation of the Cav3.2 (a1H) T-type Ca2+ channels. J. Biol. Chem. 2011; 286:2433-2444.

Calcium channel voltage-dependent T type alpha 1H subunit, CACNA1HB, Cav3.2, ECA6, EIG6

ELISA, WB, IHC-P, IF

53832009

Liquid