CAD (fosfo Thr456) Antilichaam

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.

790

P27708

NP_004332.2

Human, Mouse

CAD (phospho Thr456) antibody was raised against a peptide sequence around phosphorylation site of threonine 456 (P-I-T (p) -P-H) derived from Human CAD.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

242 kDa

IgG

The antibody detects endogenous levels of CAD only when phosphorylated at threonine 456.

CAD

Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase

Homo sapiens

Iwahana H., Biochem. Biophys. Res. Commun. 219:249-255 (1996) .

Davidson J.N., DNA Cell Biol. 9:667-676 (1990) .

Olsen J.V., Cell 127:635-648 (2006) .

PYR1, CAD protein, EC 2.1.3.2, EC 3.5.2.3

IHC

50403731

Liquid