CAD Mouse Monoclonal Antibody [Kloon ID: LBI10A3]

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Carrier-free (BSA/glycerol-free) CAD mouse monoclonal antibody, clone LBI10A3

CDG1Z; DEE50; EIEE50; GATD4

Homo sapiens carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), transcript variant 1, mRNA.

790

P27708

Unconjugated

Alanine, aspartate and glutamate metabolism, Metabolic pathways, Pyrimidine metabolism

Alanine, aspartate and glutamate metabolism, Metabolic pathways, Pyrimidine metabolism

WB 1:250~500

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CAD

https://www.ncbi.nlm.nih.gov/gene/?term=790

https://www.uniprot.org/uniprot/P27708