Cadherin 5 Antilichaam / VE Cadherin

Cadherin 5 is primarily expressed in endothelial cells, where it plays a critical role in regulating cell-cell adhesion and maintaining the integrity of the vascular barrier. Through its interactions with other Cadherin molecules and cytoskeletal components, Cadherin 5 helps to form adherens junctions, specialized structures that hold adjacent cells together and facilitate cell communication. Research has shown that mutations or dysregulation of Cadherin 5 can lead to various pathologies, including vascular dysfunction, increased permeability of blood vessels, and impaired wound healing. In addition, Cadherin 5 has been implicated in the progression of cancer, as aberrant expression of this molecule can promote tumor invasion and metastasis.

Immunofluorescence: 10 µg/mL, Flow cytometry: 1ug/million cell in 0.1ml, ELISA (peptide) LOD: 1:128000

P33151

Human

Amino acids KQARAHGKSVPE were used as the immunogen for this Cadherin 5 antibody.

IF, FACS, ELISA (peptide)

Antigen affinity

Antigen affinity purified

This Cadherin 5 antibody is available for research use only.

Aliquot and store the Cadherin 5 antibody at -20°C.

0.5 mg/mL in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide

Optimal dilution of the Cadherin 5 antibody should be determined by the researcher.

Cytoplasm, cell membrane, cell junctions

Immunofluorescent staining of fixed and permeabilized human HeLa cells with Cadherin 5 antibody (green) at 10ug/ml and DAPI nuclear stain (blue) .