Cadherine 17 Antilichaam / CDH17

Cadherin 17 (also known as LI Cadherin) is part of a family of Calcium-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. Cadherins each contain a large extracellular domain at the amino terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short carboxy terminal, intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. LI-cadherin (for liver-intestine-cadherin) expression is restricted to liver and intestine tissues and is specifically localized to the basolateral domain of hepatocytes and enterocytes.

Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 1-2 µg/mL

Q12864

Human

A portion of amino acids 242-418 from human Cadherin 17 protein was used as the immunogen for the Cadherin 17 antibody.

CDH17/2612

IHC-P, WB

Protein G affinity

Purified

This Cadherin 17 antibody is available for research use only.

Aliquot the Cadherin 17 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

1 mg/mL in 1X PBS; BSA free, sodium azide free

Optimal dilution of the Cadherin 17 antibody should be determined by the researcher.

Cell membrane, cytoplasm

Western blot testing of human small intestine tissue lysate with Cadherin 17 antibody (clone CDH17/2612) . Predicted molecular weight ~92 kDa but may be observed at higher molecular weights due to glycosylation.