Calcitroïnezuur

Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity[1][2].

71204-89-2

12352211

Drug Metabolite; VD/VDR

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Cancer; Metabolic Disease

85.0

C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC(O)=O)([H])/C(CCC1)=C/C=C3C([C@H](C[C@@H](C\3)O)O)=C

C23H34O4

374.51

[1]Kelly A Teske, et al. Synthesis and Evaluation of Vitamin D Receptor-Mediated Activities of Cholesterol and Vitamin D Metabolites. Eur J Med Chem. 2016 Jan 6;109:238–246. |[2]R P Esvelt, et al. Calcitroic acid: biological activity and tissue distribution studies. Arch Biochem Biophys. 1981 Feb;206 (2) :403-13.

Dry Ice

-80°C, protect from light, stored under nitrogen

http://file.medchemexpress.com/batch_PDF/HY-N10508/Calcitroic-acid-SDS-MedChemExpress.pdf

Natural Products

No Development Reported