Calcium-2-hydroxypropanoaat (pentahydraat)

Calcium 2-hydroxypropanoate (pentahydrate) is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator inducing lysine residues lactylation. Calcium 2-hydroxypropanoate (pentahydrate) is a glycolysis end-product, bridging the gap between glycolysis and oxidative phosphorylation. Calcium 2-hydroxypropanoate (pentahydrate) is an oncometabolite and has immune protective role of lactate in anti-tumor immunity[1][2].

5743-47-5

12352200

H302, H315, H319, H335

Endogenous Metabolite

Metabolic Enzyme/Protease

Cancer; Metabolic Disease; Inflammation/Immunology

10mM

DMSO : 100 mg/mL (ultrasonic)

O=C(C(C)O)O.[Ca].O.[0.5].[2.5]

C3H6O3.0.5Ca.2.5H2O

155.17

H302, H315, H319, H335

[1]Lucia Longhitano, et al. Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype. Int J Mol Sci. 2022 Dec 20;24 (1) :24. |[2]Qiang Feng, et al. Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity. Nat Commun. 2022 Sep 6;13 (1) :4981.

Room Temperature

4°C (Powder, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-B2227D/Calcium-2-hydroxypropanoate-pentahydrate-SDS-MedChemExpress.pdf

Biochemical Assay Reagents

No Development Reported