Calindol (hydrochloride) -13C, D2

Calindol hydrochloride-13C, d2 is the deuterium and 13C labeled Calindol hydrochloride. Calindol hydrochloride is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM[1].

1217828-76-6

12352005

CaSR; Isotope-Labeled Compounds

GPCR/G Protein; Others

Cardiovascular Disease

[2H][13C](C1=CC2=CC=CC=C2N1)(N[C@@H](C3=CC=CC4=CC=CC=C43)C)[2H].Cl

C20 13CH19D2ClN2

339.86

[1]Lionel Kiefer, et al. Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists. Bioorg Med Chem. 2016 Feb 15;24 (4) :554-69. |[2]Albane Kessler, et al. N2-benzyl-N1- (1- (1-naphthyl) ethyl) -3-phenylpropane-1,2-diamines and conformationally restrained indole analogues: development of calindol as a new calcimimetic acting at the calcium sensing receptor. Bioorg Med Chem Lett. 2004 Jun 21;14 (12) :3345-9.|[3]Harry Z E Greenberg, et al. The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca2+ channels. Eur J Pharmacol. 2016 Nov 15;791:659-668.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W777503/

Isotope-Labeled Compounds

No Development Reported