CaMK4 (fosfo Thr196/200) Antilichaam

Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2) .

814

Q16566

NP_001735.1

Human, Mouse, Rat

CaMK4 (phospho Thr196/200) antibody was raised against a peptide sequence around phosphorylation site of threonine 200 (M-K-T (p) -V-C) derived from Human CaMK4 or threonine 196 (M-K-T (p) -V-C) derived from Mouse CaMK4.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

60 kDa

IgG

The antibody detects endogenous level of CaMK4 only when phosphorylated at threonine196/threonine 200.

Western Blot: 1:500~1:1000

CAMK4

Calcium/calmodulin-dependent protein kinase IV

Homo sapiens

Oury F, et al. (2010) Genes Dev 24, 2330-42. Dias WB, Cheung WD, Wang Z, Hart GW (2009) J Biol Chem 284, 21327-37. Chow FA, Anderson KA, Noeldner PK, Means AR (2005) J Biol Chem 280, 20530-8.

CAM kinase-GR, CAMK4, CaMK IV, Calspermin, KCC4

WB

2499586

Liquid