CAND1 Antilichaam

This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants.

55832

Q86VP6

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 136kDa

IgG

CAND1

Mouse brain

Mouse heart

Mouse kidney

Mouse liver

Rat brain

Cullin-associated and neddylation-dissociated 1

Homo sapiens

TIP120A, TIP120, TIP120A

WB, IHC

Liquid