Candesartan methylester

Candesartan methyl ester (compound 14) is an antagonist for angiotensin II (AII) receptor with an IC50 of 66 nM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models[1].

139481-69-9

12352005

H228, H315, H319

Angiotensin Receptor

GPCR/G Protein

Neuroscience-Neuromodulation

Cardiovascular Disease

99.07

CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC

C25H22N6O3

454.48

H228, H315, H319

[1]Kohara Y, et al., Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres. J Med Chem. 1996 Dec 20;39 (26) :5228-35.

Room Temperature

4°C (Powder, protect from light)

http://file.medchemexpress.com/batch_PDF/HY-W098792/Candesartan-methyl-ester-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported

AT2 Receptor