Canrenon-d7

Canrenone-d7 (Aldadiene-d7) is deuterium labeled Canrenone. Canrenone (Aldadiene) is an aldosterone antagonist extensively used as a diuretic agent.

Aldadiene-d7 ; SC9376-d7

12352005

Endogenous Metabolite; Isotope-Labeled Compounds; Mineralocorticoid Receptor

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Neuroscience-Neuromodulation

Cardiovascular Disease

99.60

C[C@@]12[C@@]3(OC(C([2H])([2H])C3)=O)CC[C@@]1([H])[C@@]4([2H])[C@]([C@@]5(C(C=C4[2H])=C([2H])C(C([2H])([2H])C5)=O)C)([H])CC2

C22H21D7O3

347.50

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Erbler HC, et al. On the mechanism of the inhibitory action of the spirolactone SC 9376 (aldadiene) on the production of corticosteroids in rat adrenals in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1973;277 (2) :139-49.|[3]Caligiuri A, et al. Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology. 2003 Feb;124 (2) :504-20.|[4]Erbler HC, et al. Effect of spironolactone and its main metabolite canrenone on the renin-angiotensin-aldosterone-system during long-term treatment in rats. Acta Endocrinol (Copenh) . 1979 Jan;90 (1) :147-56.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-B1438S2/Canrenone-d7-SDS-MedChemExpress.pdf

Isotope-Labeled Compounds

No Development Reported