β-carboline-1-carbonzuur

β-Carboline 1-carboxylic acid is a β-carboline alkaloid with anti-inflammatory, antifibrotic, antitumor and antibacterial activities. β-Carboline 1-carboxylic acid is the cAMP phosphodiesterase (IC50: 96 µM) and indoleamine 2, 3-dioxygenase (IDO) inhibitor. β-Carboline 1-carboxylic acid is cytotoxic to tumor cells. β-Carboline 1-carboxylic acid inhibits inflammation through the NF-κb/p65 pathway and can reverse epithelial-mesenchymal transition (EMT) . In addition, β-Carboline 1-carboxylic acid has strong inhibitory activity against S. aureus (IC50: 47.70 μg/mL) and E. coli (IC50: 19.17 μg/mL) [1][2][3][4].

26052-96-0

12352005

H302-H315-H319-H335

Bacterial; Indoleamine 2,3-Dioxygenase (IDO) ; NF-κB; Phosphodiesterase (PDE)

Anti-infection; Metabolic Enzyme/Protease; NF-κB

Cancer; Infection; Inflammation/Immunology

O=C(C1=NC=CC2=C1NC3=C2C=CC=C3)O

C12H8N2O2

212.20

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Cui Y, et al. β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition. J Ethnopharmacol. 2019 Oct 28;243:112096.|[2]Sung Y, et al. Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides Bennet, and inhibitory activities of related beta-carboline alkaloids. Chem Pharm Bull (Tokyo) . 1984 May;32 (5) :1872-7.|[3]Wang N, et al. Discovery of potent indoleamine 2,3-dioxygenase (IDO) inhibitor from alkaloids in Picrasma quassioides by virtual screening and in vitro evaluation. Fitoterapia. 2019 Mar;133:137-145.|[4]Hu H, et al. Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides' Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometry Combined With Fragmentation and Retention Time Calculation. Front Pharmacol. 2021 Oct 27;12:761751.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-29268/

Reference compound1

No Development Reported