CARD10 Antilichaam

CARD10 Antibody: Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10. This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-κ B. CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the Iκ K complex, demonstrating its importance in the regulation of NF-κ B transcription factor activation.

29775

Q9BWT7

AAK26165

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis

CARD10 Antibody is immunoaffinity purified .

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

CARD10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

CARD10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

CARD10

Cat. No. 1288 - A20 Cell Lysate

Cat. No. 17-207 - EL4 Cell Slide

Caspase recruitment domain family, member 10

Homo sapiens

Wang L, Guo Y, Huang W-J, et al. CARD10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappaB. J. Biol. Chem. 2001; 276:21405-9.

Fanning AS and Anderson JM. Protein modules as organizers of membrane structure. Curr. Opin. Cell Biol. 1999; 11:432-9.

Fischer KD, Tedford K, Wirth T. New roles for Bcl10 in B-cell development and LPS response. Trends Immunol. 2004; 25:113-6.

Stilo R, Liguoro D, Di Jeso B, et al. Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase kappa-NF-kappaB essential modulator. J. Biol. Chem. 2004; 279:34323-31.

CARD10 Antibody: BIMP1, CARMA3, Caspase recruitment domain-containing protein 10, CARD-containing MAGUK protein 3, Carma 3

ELISA, WB, ICC, IF

13488607

Liquid