β-Caroteen-13C10

β-Carotene-13C10 (Provitamin A-13C10) is the 13C-labeled β-Carotene. β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities[1][2][3][4][5].

301150-50-5

Provitamin A-13C10; beta-Carotene-13C10

12352211

H315, H319, H335

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds; Reactive Oxygen Species (ROS)

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Metabolism-sugar/lipid metabolism

Cancer; Metabolic Disease

98.16

CC1(C)C(/C=C/C(C)=C/C=[13CH]/[13C]([13CH3])=[13CH]/[13CH]=[13CH]/[13CH]=[13C]([13CH3])/[13CH]=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)=C(C)CCC1

C30 13C10H56

546.80

H315, H319, H335

[1]Tanumihardjo, S.A., Factors influencing the conversion of carotenoids to retinol: bioavailability to bioconversion to bioefficacy. Int J Vitam Nutr Res, 2002. 72 (1) : p. 40-5.|[2]Leo, M.A., et al. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr, 1999. 69 (6) : p. 1071-85. |[3]Yanhong Cui, et al. beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer. 2007 Nov;43 (17) :2590-601.|[4]AKIFUMI KAWATA, et al. Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species. In Vivo. 2018 Mar-Apr; 32 (2) : 255-264. |[5]Paola Palozza, et al. Prooxidant effects of beta-carotene in cultured cells. Mol Aspects Med. 2003 Dec;24 (6) :353-62.

Blue Ice

-20°C (Powder, protect from light, stored under nitrogen)

http://file.medchemexpress.com/batch_PDF/HY-N0411S4/β-Carotene-13C10-SDS-MedChemExpress.pdf

Isotope-Labeled Compounds

No Development Reported