β-Caroteen-15,15'-epoxide

β-carotene-15,15ʹ-epoxide is a XIAP antagonist with apoptosis-inducing and antitumor activity, found in the leaves of Spondias mombin. In a DMBA -induced rat model of breast cancer, β-carotene-15,15ʹ-epoxide binds to the BIR3 domain of the anti-apoptotic protein XIAP, blocking its interaction with caspase-9 and thereby promoting tumor cell apoptosis. In addition, β-carotene-15,15ʹ-epoxide significantly downregulates the expression of BCL-2, COX-2, and TNF-α in tumor tissues, reduces MDA levels, increases catalase activity, and modulates serum levels of LDH, ALP, and ALT, demonstrating strong antioxidant, anti-inflammatory, and metabolic protective effects. β-carotene-15,15ʹ-epoxide may be used in research on inflammation-related conditions and cancers such as breast cancer[1].

132541-62-9

12352005

Apoptosis; Bcl-2 Family; Caspase; COX; IAP; TNF Receptor

Apoptosis; Immunology/Inflammation

Cancer; Inflammation/Immunology

CC(CCCC1(C)C)=C1/C=C/C(C)=C/C=C/C(C)=C/C2OC2/C=C(C)/C=C/C=C(C)/C=C/C3=C(CCCC3(C)C)C

C40H56O

552.87

[1]Metibemu DS, et al. Carotenoid isolates of Spondias mombin demonstrate anticancer effects in DMBA-induced breast cancer in Wistar rats through X-linked inhibitor of apoptosis protein (XIAP) antagonism and anti-inflammation. J Food Biochem. 2020 Dec;44 (12) :e13523.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N15378/

Natural Products

No Development Reported