CASC5 Antilichaam

The protein encoded by this gene is a component of the multiprotein assembly that is required for creation of kinetochore-microtubule attachments and chromosome segregation. The encoded protein functions as a scaffold for proteins that influence the spindle assembly checkpoint during the eukaryotic cell cycle and it interacts with at least five different kinetochore proteins and two checkpoint kinases. In adults, this gene is predominantly expressed in normal testes, various cancer cell lines and primary tumors from other tissues and is ubiquitously expressed in fetal tissues. This gene was originally identified as a fusion partner with the mixed-lineage leukemia (MLL) gene in t (11;15) (q23; q14) . Mutations in this gene cause autosomal recessive primary microcephaly-4 (MCPH4) . Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described but their biological validity has not been confirmed.

57082

Q8NG31

Human, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CASC5 (NP_733468.3) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Stem Cell

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 300kDa

IgG

CASC5

U-87MG

HeLa

Jurkat

Kinetochore scaffold 1

Homo sapiens

AF15Q14, CASC5, CT29, D4MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105, kinetochore scaffold 1, ALL1-fused gene from chromosome 15q14 protein, blinkin, bub-linking kinetochore protein, cancer susceptibility candidate 5, cancer susceptibility candidate gene 5 protein, cancer/testis antigen 29, kinetochore null 1 homolog, kinetochore-null protein 1, microcephaly, primary autosomal recessive 4, protein phosphatase 1, regulatory subunit 55

WB, IHC, IF

Liquid