CASP1 Antilichaam - middengebied: HRP (ARP58983 P050-HRP)

Caspase 1, apoptosis-related cysteine peptidase

ICE, P45, IL1BC

834

P29466

NP_001214

Human, Horse, Rabbit, Yeast

The immunogen is a synthetic peptide directed towards the middle region of human CASP1

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms.

Ced-3; ced-4; VAC14; BCL2L1; UBC; XK; PLA2G4B; IL33; IL1B; PARP1; BIRC3; TRAF2; CEBPB; TIRAP; CARD17; CARD16; CARD8; PLA2G4A; CDK11B; NLRP1; ATN1; ATXN3; PYCARD; NLRC4; NOD1; CASP14; RIPK2; PAK1; PARK2; NEDD4; BID; IL18; PSEN2; NFE2L2; AR; BCAP31; MAPT; L

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

CASP1 is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Horse: 79%; Human: 100%; Rabbit: 79%; Yeast: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

10kDa

Wet Ice

383

CASP1

CASP1

Rabbit

Caspase-1

NM_001223

LQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGAQACQICITYICEE