CASP10 Antilichaam - middengebied: Biotine (ARP59000 P050-Biotine)

Caspase 10, apoptosis-related cysteine peptidase

MCH4, ALPS2, FLICE2, FLICE-2

843

Q92851

NP_001221

Human

The immunogen is a synthetic peptide directed towards the middle region of human CASP10

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.

FADD; PRDX6; XIAP; RB1; Dlg4; PHF20L1; OIP5; ECE2; RIOK3; NFKBIL1; CASP8; RNF34; BFAR; CASP8AP2; MSN2; PTC2; AIM9; GLN3; SLT2; GPA1; STE20; ATG13; RPL21B; VPS30; CUP9; TPK2; GAL4; FAR11; WHI3; ATG4; FAR3; FAR8; ITT1; MPH1; SSM4; ASG1; BFR1; ORT1; MBR1; CW

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

12kDa

Wet Ice

479

CASP10

CASP10

Rabbit

Caspase-10

NM_001230

HNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIP