CASP5 Antilichaam - middengebied: HRP (ARP58992 P050-HRP)

Caspase 5, apoptosis-related cysteine peptidase

ICH-3, ICEREL-III, ICE (rel) III

838

P51878

NP_001129581

Human, Cow, Guinea Pig

The immunogen is a synthetic peptide directed towards the middle region of human CASP5

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.

PPHLN1; NLRP1; CASP5; MAX

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 83%; Guinea Pig: 82%; Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

43kDa

Wet Ice

376

CASP5

CASP5

Rabbit

Caspase-5

NM_001136109

VIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFI