CASP6 Antilichaam - middengebied HRP (ARP58994 P050-HRP)

Caspase 6, apoptosis-related cysteine peptidase

MCH2

839

P55212

NP_001217

Human, Mouse, Pig

The immunogen is a synthetic peptide directed towards the middle region of human CASP6

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms.

CASP6; XIAP; CRYAB; UBC; CASP3; RB1; IKBKG; PRKAB2; SP1; COPS6; SATB1; TAB1; MAPK6; PIN1; UBE4A; NUAK1; UBE4B; CHD3; PSME3; EIF2S1; CFLAR; PPL; NEDD4; SRP72; CASP8; CASP10; TRAF1; PSEN2; SRF; VIM; PRKCZ; MAPT; LMNB1; LMNA; KRT18; HTT; TOP1; DSP; PCYT1A; T

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Human: 100%; Mouse: 82%; Pig: 77%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

33kDa

Wet Ice

293

CASP6

CASP6

Rabbit

Caspase-6

NM_001226

QACRGNQHDVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCY