CASP8 Antilichaam - middengebied HRP (ARP58883 P050-HRP)

Caspase 8

CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8

841

Q14790-9

NP_001073594.1

Human

The immunogen is a synthetic peptide directed towards the middle region of human CASP8

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

BAX; ced-4; FADD; UBC; ERLIN2; PRDX6; TNF; CRYAB; XIAP; TNFSF10; RIPK1; HECTD3; SQSTM1; GZMB; PLA2G4B; RB1; PLIN4; BCAP31; PDIA6; CFLAR; SNRPD3; PRKCI; BIRC2; RIPK3; TNFRSF10A; TNFRSF10B; CUL3; TRAF2; CASP10; PARK7; LRRK2; CARD11; FIS1; CASP3; FASLG; TOPO

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity purified

0.5 mg/ml

Human: 100%; Mouse: 92%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

59 kDa

Wet Ice

538

CASP8

CASP8

Rabbit

Caspase-8

NM_001080124.1

SPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINN