Caspase-1 Antilichaam

Caspase-1 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Caspase-1 was initially identified as an IL-1β -converting enzyme; later experiments revealed it to be a mammalian homolog of the C. elegans cell death gene ced-3 whose overexpression can induce apoptosis in fibroblasts.

834

P29466

NP_150634

Human

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Inflammasomes

Caspase-1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1301 - Human Heart Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (88%), Pig: (81%), Horse: (81%)

Caspase-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Caspase-1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Depending on cell lines or tissues used, other cleavage products may be observed.

CASP1

Cat. No. 10-501 - Human Heart Tissue Slide

Caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Homo sapiens

Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.

Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 β converting enzyme. Science 1995; 267:2000-3.

Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.

Caspase-1 Antibody: ICE, P45, IL1BC, IL1BCE, Caspase-1, Interleukin-1 beta convertase, CASP-1

ELISA, WB, IHC-P

15431328

Liquid