Caspase-10 Antilichaam

Caspase-10 Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) - containing adapter molecules and members of the ICE/CED-3 protease family. A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 and renamed as caspase-10. Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors. Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP. Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death. Caspase-10 is expressed in many tissues and cell lines.

843

Q92851

AAD28402

Human

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Caspase-10 Antibody is DEAE purified.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/ml

Caspase-10 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Caspase-10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Antibody only recognizes FLICE2 form of caspase-10.

CASP10

Cat. No. 1205 - Jurkat Cell Lysate

Cat. No. 1202 - A431 Cell Lysate

Cat. No. 1204 - K562 Cell Lysate

Caspase 10, apoptosis-related cysteine peptidase

Homo sapiens

Vincenz.C. and Dixit, V.M. Fas-associated death domain protein interleukin-1β -converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. 1997;272:6578-6583

Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl. Acad. Sci. USA. 1996;93:7464-7469

Cohen GM. Caspases: the executioners of apoptosis. Biochem J 1997;326:1-16 (RD1299)

Caspase-10 Antibody: MCH4, Caspase-10, Apoptotic protease Mch-4, CASP-10

ELISA, WB, IF, ICC

4731237

Liquid