Caspase-12 Antilichaam

Caspase-12 Antibody: Three distinct signaling pathways lead to programmed cell death (apoptosis) . The death receptor and mitochondrion pathways are the mains, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP) . Caspase-12 mediates cytotoxicity induced by amyloid-beta.

12364

O08736

CAA73532

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Caspase-12 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1403 - Mouse Brain Tissue Lysate

1 mg/mL

Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Caspase-12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Casp12

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Cat. No. 1404 - Mouse Liver Tissue Lysate

Caspase 12

Mus musculus

Nakagawa T, Zhu Human, Mouseorishima N, el al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β . Nature 2000; 403:98-103.

Mehmet H. Caspases find a new place to hide. Nature 2000; 403:29-30

Van de Craen M, Vandenabeele P, Declercq W, et al. Characterization of seven murine caspase family members. FEBS Lett 1997; 403:61-9.

Caspase-12 Antibody: Caspase-12, CASP-12

ELISA, WB, IHC-P, IF

2094806

Liquid