Caspase-12 Antilichaam (Groot)

Caspase-12 Antibody: (Large) Three distinct signaling pathways lead to programmed cell death (apoptosis) . The death receptor and mitochondrion pathways are the main, in which the key apoptotic proteases capase-8 and caspase-9, respectively, are involved. The endoplasmic reticulum (ER) stress is the third apoptotic pathway and caspase-12 is involved. Caspase-12 is localized to the ER but not to cytoplasm or mitochondrion. Caspase-12 is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis. Caspase-12 is co-localized to the ER with several proteins that are involved in Alzheimer's disease including gamma-secretase presenilin and beta-amyloid precursor protein (APP) . Caspase-12 mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.

12364

O08736

CAA73532

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Caspase-12 (Large) Antibody is affinity chromatography purified via peptide column.

Cat. No. 1301 - Human Heart Tissue Lysate

1 mg/mL

Caspase-12 Antibody is supplied in PBS containing 0.02% sodium azide. (Large)

None

Blue Ice

Caspase-12 (Large) antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Caspase-12 (large) antibody is predicted to have no cross reactivity to other members in the caspase family.

Casp12

Cat. No. 1401 - Mouse Heart Tissue Lysate

Cat. No. 10-501 - Human Heart Tissue Slide

Cat. No. 1461 - Rat Heart Tissue Lysate

Caspase 12

Mus musculus

Nakagawa T, Zhu H, Morishima N, et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β . Nature 2000; 403:98-103.

Mehmet H. Caspases find a new place to hide. Nature 2000; 403:29-30

Van de Craen M, Vandenabeele P, Declercq W, et al. Characterization of seven murine caspase family members. FEBS Lett. 1997; 403:61-9

Caspase-12 (Large) Antibody: Caspase-12, CASP-12

ELISA, WB, IHC-P, IF

2094806

Liquid