Caspase-2 Antilichaam

Caspase-2 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12 and can activate proinflammatory cytokines such as IL-1β and IL-18. Although phylogenetically similar to this subfamily, Caspase-2 is thought to be involved in stress-induced apoptosis. Caspase-2 has two major isoforms; overexpression on the long form results in apoptosis while that of the short form suppresses cell death.

835

P42575

P42575

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Caspase-2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1314 - Human Thymus Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Chicken: (75%)

Caspase-2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Caspase-2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Depending on cell lines or tissues used, other cleavage products may be observed.

CASP2

Cat. No. 1305 - Human Kidney Tissue Lysate

Cat. No. 1288 - A20 Cell Lysate

Caspase 2, apoptosis-related cysteine peptidase

Homo sapiens

Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

Zhivotovsky B and Orrenius S. Caspase-2 funtion in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.

Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 β converting enzyme. Science 1995; 267:2000-3.

Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.

Caspase-2 Antibody: ICH1, NEDD2, CASP-2, NEDD-2, PPP1R57, ICH1, Caspase-2, Neural precursor cell expressed developmentally down-regulated protein 2

ELISA, WB, ICC

83300977

Liquid