Caspase-3/7 Remmer I

Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin -treated Jurkat cells and in chondrocytes[1][2].

1110670-49-9

12352005

Apoptosis; Caspase

Apoptosis

Cancer

98.31

DMSO : 100 mg/mL (ultrasonic)

O=C1NC2=C(C=C(S(=O)(N3C(COC)CCC3)=O)C=C2)C1=O

C14H16N2O5S

324.35

[1]Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem. 2000 May 26;275 (21) :16007-14.|[2]Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44 (12) :2015-26.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-W033813/Caspase-3-7-Inhibitor-I-SDS-MedChemExpress.pdf

Reference compound1

Phase 1