Caspase-4 Antilichaam

Caspase-4 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1β and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease.

837

P49662

AAA86890

Human, Mouse

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Neuroscience, Inflammasomes

Caspase-4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1225 - Ramos Cell Lysate

1 mg/mL

Caspase-4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Caspase-4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Depending on cell lines or tissues used, other cleavage products may be observed.

CASP4

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Caspase 4, apoptosis-related cysteine peptidase

Homo sapiens

Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 β converting enzyme. Science 1995; 267:2000-3.

Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224.

Kamens J, Paskind M, Hugunin M, et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 β -converting enzyme family of cysteine proteases. J. Biol. Chem. 1995; 270:15250-6.

Caspase-4 Antibody: TX, ICH-2, Mih1/TX, ICEREL-II, ICE (rel) II, ICH2, Caspase-4, Protease ICH-2, CASP-4

ELISA, WB, IHC-P, IF

886050

Liquid