Caspase-8 Antilichaam

Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.

841

Q14790

NP_001219

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Apoptosis, Neuroscience, Autophagy, Cancer, Inflammasomes

Caspase-8 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

Caspase-8 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Caspase-8 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

55 kDa

IgG

Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.

CASP8

Cat. No. 1306 - Human Spleen Tissue Lysate

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Cat. No. 1466 - Rat Spleen Tissue Lysate

Cat. No. 10-901 - Human Spleen Tissue Slide

Cat. No. 17-005 - Jurkat Cell Slide

Caspase 8, apoptosis-related cysteine peptidase

Homo sapiens

Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117:561-74.

Zhivotovsky B and Orrenius S. Caspase-2 function in response to DNA damage. Biochim. Biophys. Res. Comm. 2005; 331:859-67.

Wolf BB and Green DR. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. 1999; 274:20049-52.

Muzio M, Chinnaiyan AM, Kischkel FC, et al. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 1996; 85:817-27.

Caspase-8 Antibody: CAP4, MACH, MCH5, FLICE, ALPS2B, Casp-8, Caspase-8, Apoptotic cysteine protease, CASP-8

ELISA, WB, IHC-P, ICC, IF

15718704

Liquid