Caspase 9 Antilichaam

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

842

P55211

NP_001220.2

Human

Caspase 9 antibody was raised against a peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9.

Unconjugated

Primary Antibodies

Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

47, 37, 35 kDa

This antibody detects endogenous level of total Caspase 9 protein.

Western Blot: 1:1000

CASP9

Caspase 9, apoptosis-related cysteine peptidase

This antibody was raised against a peptide sequence around aa.301~305 (T-S-P-E-D) derived from Caspase 9

Zou, H. et al. (1999) J. Biol. Chem. 274, 11549-11556. Deveraux, Q. L. et al. (1998) EMBO J. 17, 2215-2223. Li, P. et al. (1997) Cell 91, 479-489.

MCH6, APAF3, APAF-3, PPP1R56, ICE-LAP6, DXS423E, KIAA0178, SB1.8, SMC1, SMC1L1, ICE-like apoptotic protease 6

WB

14790124

Liquid