Caspase 9 (fosfo Thr125) Antilichaam

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Proteolytically cleaves poly (ADP-ribose) polymerase (PARP) . Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

842

P55211

NP_001220.2

Human, Mouse, Rat

Caspase 9 (phospho Thr125) antibody was raised against a peptide sequence around phosphorylation site of threonine 125 (P-E-T (p) -P-R) derived from Human Caspase 9.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

47 kDa

IgG

The antiserum was produced against synthesized phosphopeptide derived from human Caspase 9 around the phosphorylation site of threonine 125 (P-E-TP-P-R) .

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

CASP9

Caspase 9, apoptosis-related cysteine peptidase

Homo sapiens

Duan H., J. Biol. Chem. 271:16720-16724 (1996) .

Srinivasula S.M., J. Biol. Chem. 271:27099-27106 (1996) .

Hadano S., Mamm. Genome 10:757-760 (1999)

APAF-3, MCH6, RNCASP9, CASP-9, ICE-LAP6

WB, IHC

14790124

Liquid