CAST Antilichaam

The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.

831

P20810

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 550-650 of human CAST (NP_001177371.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Neuroscience

Affinity purification

A-549

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 130kDa

IgG

CAST

NCI-H460

Mouse lung

Rat liver

Calpastatin

Homo sapiens

Calpastatin, Calpain inhibitor, BS-17, Calpastatin

WB, IF

Liquid