Cathepsin L (CTSL) Mouse Monoclonal Antibody [Kloon ID: LBI8C12]

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Carrier-free (BSA/glycerol-free) CTSL1 mouse monoclonal antibody, clone LBI8C12

CATL; CTSL1; MEP

Homo sapiens cathepsin L (CTSL), transcript variant 1, mRNA.

1514

P07711

Unconjugated

Antigen processing and presentation, Lysosome

Antigen processing and presentation, Lysosome

WB 1:2000, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome, Protease

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

CTSL

https://www.ncbi.nlm.nih.gov/gene/?term=1514

https://www.uniprot.org/uniprot/P07711