Caudal type homeobox transcriptie factor 2 Antilichaam / CDX2

The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoidsand is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma.However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.

Immunohistochemistry (FFPE) : 1-2 µg/mL

Q99626

Human

A portion of amino acids 150-249 from human CDX2 protein was used as the immunogen for the Caudal type homeobox transcription factor 2 antibody.

CDX2/9338

IHC-P

Protein G affinity

Purified

This Caudal type homeobox transcription factor 2 antibody is available for research use only.

Aliquot the Caudal type homeobox transcription factor 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

1 mg/mL in 1X PBS; BSA free, sodium azide free

Optimal dilution of the Caudal type homeobox transcription factor 2 antibody should be determined by the researcher.

Nucleus

IHC staining of FFPE human colon tissue with Caudal type homeobox transcription factor 2 antibody (clone CDX2/9338) . Inset: PBS used in place of primary Ab (secondary Ab negative control) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.