Caveoline 1 (Ab 14) Antilichaam

The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.

857

Q03135

NP_001166366.1

Human, Mouse, Rat

Caveolin-1 (Ab-14) antibody was raised against a peptide sequence around aa.12~16 (H-L-Y-T-V) derived from Human CAVEOLIN-1.

Unconjugated

Primary Antibodies

Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

24 kDa

This antibody detects endogenous level of total Caveolin-1 protein.

Western Blot: 1:500~1:1000

CAV1

Caveolin 1, caveolae protein, 22kDa

Homo sapiens

Zhang Y, et al. (2005) Mol Cell Proteomics. 4 (9) : 1240-1250. Labrecque L, et al. (2004) J Biol Chem. 279 (50) : 52132-52140. Fielding PE, et al. (2004) Biochemistry. 43 (9) : 2578-2586. Labrecque L, et al. (2003) Mol Biol Cell. 14 (1) : 334-347. Maggi D, et al. (2002) Biochem Biophys Res Commun. 295 (5) : 1085-1089.

CGL3, PPH3, BSCL3, VIP21, MSTP085, CAV, CAV1

WB

290542359

Liquid