Caveoline-1 Antilichaam

Caveolin-1 Antibody: Caveolin-1 is a scaffolding protein that is the main component of the caveolae plasma membranes found in most cell types (1) . The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression (2) . The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade (3) . Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy (4) .

857

Q03135

NP_001744

Human, Mouse, Rat

Caveolin-1 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human Caveolin-1.

Unconjugated

Primary Antibodies

Signal Transduction, Cancer, Cell Cycle

Caveolin-1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1302 - Human Lung Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (100%), Horse: (100%), Sheep: (100%), Bovine: (100%), Pig: (100%), Chicken: (88%)

Caveolin-1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Caveolin-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of Caveolin-1 are known to exist; this antibody will detect only the largest isoform.

CAV1

Caveolin 1

Homo sapiens

Glenney JR Jr. The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles. FEBS Lett. 1992; 314:45-8.

Wary KK, Mariotti A, Zurzolo C, et al. A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 1998; 94:625-34.

Capozza F, Williams TM, Schubert W, et al. Absence of caveolin-1 sensitizes mouse skin to carcinogen-induced epidermal hyperplasia and tumor formation. Am. J. Pathol. 2003; 162:2029-39.

Kim CA, Delepine M, Boutet E, et al. Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J. Clin. Endocrinol. Metab. 2008; 93:1129-34.

Caveolin-1 Antibody: Caveolin-1, BSCL3, CGL3, LCCNS, MSTP085, PPH3, VIP21

ELISA, WB

15451856

Liquid