CB-5339-NL-C

CB-5339 is an oral activity potent p97 inhibitor with an IC50 [1]. CB-5339 extracted from WO2015109285A1 compound FF07.

1863952-15-1

12352005

P97

Reference compound

Cell Cycle/DNA Damage

Cancer-programmed cell death

Cancer

https://www.medchemexpress.com/cb-5339.html

99.58

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(CCCN5)C5=N3)N

C24H24N6O

412.49

[1]David Wustrow, et al. FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX. WO2015109285A1.|[2]Roux B, et.al. Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor. Sci Transl Med. 2021 Mar 31;13 (587) :eabg1168.

Blue Ice

-20°C, 3 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-128724/CB-5339-SDS-MedChemExpress.pdf

Reference compound1

Phase 1