CB-839
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
CB-839 is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC) .1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line, HCC-1806, but no activity in the estrogen receptor-positive cell line T47D. CB-839 was able to cause proliferation arrest and apoptosis in acute myeloid leukemia cells without causing cytotoxicity against normal human CD34 (+) progenitors.2 Aspartate-glutamate carrier 1 (AGC1) inhibition can synergize with CB-839 to limit tumor growth.3
Unconjugated
Pale yellow solid
-20°C
Beschrijving
CB-839 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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